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Microencapsulation & Cell Biology Applications

Ultrasonic Nozzles for Microencapsulation


Ultrasonic spray nozzles have long been recognized as an ideal tool for microencapsulation. Their characteristic low-velocity spray, easily controllable drop size (drop diameter is determined by nozzle frequency), and non-clogging design provide a perfect fit for many applications.

One method of using this unique technology for microencapsulation consists of spraying a liquid containing solids that immediately dry in the air after atomization takes place, and fall gently into a liquid bath, creating encapsulated particles.

Another method uses Sono-Tek’s new dual liquid feed option (shown below) allowing for even greater flexibility in your process. With the appropriate chemistry, two liquids can be mixed right at the nozzle’s atomizing surface.

Ultrasonic Spray Nozzle advantages:

  • Ultrasonic atomization produces a tight and controllable drop size distribution
  • Non-clogging ultrasonic nozzle is easy to clean, with low maintenance
  • Capable of micro-quantity dispensing
  • Produces low-velocity, spherical drops
  • Dual liquid feed avoids premature mixing of components

Frequencies available from 25 – 120 kHz, depending on your drop size requirements. To determine what nozzle system will best meet your needs, please feel free to speak with one of our sales engineers by filling out our information request form below.

Dual Liquid Feed Operating Principle

dual-feed-nozzle2

Applications include but are not limited to:

  • Targeted drug delivery
  • Slow release pharmaceuticals
  • Functional foods
  • Spices and flavorings
  • Aromas
  • Nanoencapsulation
  • Cosmetics
  • Pesticides
  • Pigments and dyes
  • Lubricants
  • Emulsions
  • High solids dispersions
  • Solgels
  • Catalysts
  • *Process development not supported

Ultrasonic Nozzles for Cell Biology & Immunology Research


hairy root

Vortex spraying close up

Sono-Tek ultrasonic nozzles are proven successful in gas phase, or mist bioreactor systems, for the production of biomass hairy root cultures. Homogeneous pharmaceutical monoclonal antibodies are extracted for use in cancer treatment, pharmaceutical and bioengineering research. The ability to fine tune mist properties such as flow rate, droplet size and duty cycle timing results in significantly higher biomass yield than shake flask or airlift cultures (as much as 50% higher yield). Ultrasonic atomization has shown to be a low cost scalable solution for production of small molecule compounds and proteins from tobacco or other hairy roots. Sono-Tek ultrasonic mist systems have been shown to produce more favorable root density with improved gas exchange than liquid-phase reactors.


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